- Associate Professor, Department of Medicine - Section of Pulmonary and Critical Care Medicine, Committee on Cell Physiology, Committee on Molecular Medicine/MPMM
Ph.D., National Cardiology Research Center, 1992
MD, Moscow State Medical School, 1986
The University of Chicago
929 East 57th Street
Chicago, Illinois 60637
Phone: (773) 834-2636
Dr. Birukov’s laboratory addresses molecular mechanisms involved in the regulation of lung vascular permeability under physiological and pathological conditions associated with ventilator-induced lung injury or bacterial lypopolysacharide-induced inflammation, including 1) Role of small GTPases Rac and Rho in magnitude-dependent regulation of lung endothelial cytoskeleton and permeability; 2) Evaluation of the Rac and Rho effectors within the focal adhesions and adherens junctions involved in mechanochemical regulation of vascular permeability; 3) Novel barrier-protective and anti-inflammatory effects of oxidized phospholipids on the lung endothelium in acute lung injury.