Basic science courses listed below are offered by various departments within the Biological Sciences Division. Students are encouraged (but not required) to take three of these courses based on their particular needs and/or educational backgrounds.
Protein Fundamentals This course covers the physical-chemical phenomena that define protein structure and function. Topics include: the principles of protein folding, molecular motion and molecular recognition; protein evolution, design and engineering; enzyme catalysis; regulation of protein function and molecular machines; proteomics and systems biology. Prereq: introductory biochemistry. Koide, Keenan; Autumn.
Cell Biology 1 Eukaryotic protein traffic and related topics, including molecular motors and cytoskeletal dynamics, organelle architecture and biogenesis, protein translocation and sorting, compartmentalization in the secretory pathway, endocytosis and exocytosis, and mechanisms and regulation of membrane function. Turkewitz, Glick; Autumn.
Cell Biology 2 This course covers the mechanisms with which cells execute fundamental behaviors. Topics include signal transduction, cell cycle progression, cell growth, cell death, cancer biology, cytoskeletal polymers and motors, cell motility, cytoskeletal diseases, and cell polarity. Each lecture will conclude with a dissection of primary literature with input from the students. Students will write and present two short research proposals. Cell Bio 1 is not a prerequisite. Glotzer, Kovar; Winter.
Genetics and Systems Approaches
Genetic Analysis of Model Organisms Fundamental principles of genetics discussed in the context of current approaches to mapping and functional characterization of genes. The relative strengths and weaknesses of leading model organisms are emphasized via problem-solving and critical reading of original literature. Palmer; Autumn.
Human Genetics 1 This course covers classical and modern approaches to studying cytogenetic, Mendelian, and complex human diseases. Topics include chromosome biology, single gene and complex diseases, non-Mendelian inheritance, cancer genetics, human population genetics, and genomics. The format includes lectures and student presentations. Ober, Gilad, Nobrega; Autumn.
Genomics and Systems Biology This lecture course explores the technologies that enable high-throughput collection of genomic-scale data, including sequencing, genotyping, gene expression profiling, assays of copy number variation, protein expression and protein-protein interaction. We also cover study design and statistical analysis of large data sets, as well as how data from different sources can be used to understand regulatory networks (i.e., systems). Statistical tools introduced include linear models, likelihood-based inference, supervised and unsupervised learning techniques, methods for assessing quality of data, hidden Markov models, and controlling for false discovery rates in large data sets. Gilad, Nicolae; Spring.
Molecular Biology 1 Nucleic acid structure and DNA topology; methodology; nucleic-acid protein interactions; mechanisms and regulation of transcription in eubacteria, and of replication in eubacteria and eukaryotes; mechanisms of genome and plasmid segregation in eubacteria. Rothman-Denes; Winter.
Molecular Biology 2 The content of this course will cover the mechanisms and regulation of eukaryotic gene expression at the transcriptional and post-transcriptional levels. Our goal is to explore research frontiers and evolving methodologies. Rather than focusing on the elemental aspects of a topic, the lectures and discussions highlight the most significant recent developments, their implications, and future directions. Staley, Ruthenburg; Spring.