Murray Favus, M.D.


  • Professor, Department of Medicine - Section of Endocrinology, Committee on Molecular Metabolism and Nutrition


M.D., The University of Chicago, 1967
B.S., The University of Illinois, 1963


The University of Chicago
AMB M247, (MC 1027)
5841 South Maryland Avenue
Chicago, Illinois 60637

Phone: (773) 702-6227


Bone Loss in Women; Molecular Regulation of Renal Metabolism of Vitamin D and Calcium, Pathogenesis of Calcium Metabolism in Calcium Kidney Stone Formation

In the area of calcium metabolism, he has identified increases in intestinal and bone vitamin D receptor content in genetic hypercalciuric kidney stone forming rats, an animal model of human idiopathic hypercalciuria. This description represents one of the first examples of a disorder (hypercalciuria and stone formation) caused by a pathologic excess of a steroid hormone. In other studies, Dr. Favus has defined the protein kinase C signaling pathway in rat renal proximal tubules as mediating parathyroid hormone stimulation of the 25-hydroxyvitamin D-1-hydroxylase, a key regulatory enzyme in the vitamin D activation pathway. By this work he was able to assign a pathway to one of parathyroid hormone’s many biologic actions. In clinical studies, Dr. Favus participated in the multi-center trial that found the bisphosphonate alendronate sodium to be effective in the treatment of postmenopausal osteoporosis and he continues to conduct clinical studies that aim to characterize novel approaches to the treatment of osteoporosis and disorders of calcium metabolism.

Research Papers in PubMed