Tatyana V. Golovkina, Ph.D.

APPOINTMENTS

  • Professor, Department of Microbiology, Committee on Immunology, Committee on Microbiology

CONTACT INFORMATION

The University of Chicago 
CLSC 711A
920 East 58th Street 
Chicago, Illinois 60637

tgolovki@bsd.uchicago.edu

Phone:  (773) 834-7988

RESEARCH SUMMARY

Tatyana received her M.S. in Biochemistry from Moscow State University, Moscow, USSR.  She pursued graduate studies at the USSR Academy of Medical Sciences Cancer Research Center, Moscow, USSR in the laboratory of Andrei Gudkov.  Her doctoral thesis describes studies on evolution of endogenous retroviruses in mammalian genome. She then joined Susan Ross’ laboratory at the Department of Biochemistry, University of Illinois at Chicago and later moved with the lab to University of Pennsylvania, Department of Microbiology. She joined The Jackson Laboratory in Bar Harbor, ME in 1997 where she studied genetics of resistance to viral infection and in 2005, she re-located her laboratory to the Department of Microbiology at the University of Chicago.

Tatyana’s laboratory uses different retroviruses to study distinct aspects of retrovirus-host interactions, including the anti-virus immune response and the genetics of resistance to retroviral infection and to virally induced tumors.  Recently her laboratory became interested in understanding the mechanisms by which commensal bacteria colonized in the gut influence the outcome of viral infections.  By using germ-free mice, they found that retroviruses that spread through the gastrointestinal route exploit commensal bacteria to induce tolerance to themselves.  Unresponsiveness of the infected host enables the viruses to persist indefinitely.  Elucidation of the mechanism of retroviral pathogenesis is of fundamental importance, as it will ultimately lead to increased knowledge about the anti-virus immune response in general and variations in susceptibility to viral infections in humans.

SELECTED PAPERS

Golovkina T, Shlomchik M, Hannum L, Chervonsky A.  1999.  Organogenic role of B lymphocytes in mucosal immunity.  Science 286(5446):1965-1968.

Golovkina TV.  2000.  A novel mechanism of resistance to mouse mammary tumor virus infection.  J Virol 74(6):2752-2759.

Hook LM, Agafonova Y, Ross SR, Turner SJ, Golovkina TV.  2000.  Genetics of MMTV-induced mammary tumors; linkage of tumor-induction to the gag gene.  J Virol 74(19):8876-8883.

Golovkina TV, Agafonova Y, Kazansky D, Chervonsky AV.  2001.  Diverse repertoire of the MHC class II-peptide complexes is required for presentation of viral superantigens.  J Immunol 166:2244-2250.

Hook LM, Jude BA, Ter-Grigorov VS, Hartley JW, Morse HC III, Trainin Z, Toder V, Chervonsky AV, Golovkina TV.  2002.  Characterization of a novel murine retrovirus mixture that facilitates hematopoiesis.  J Virol 76:12112-12122.

Jude B,  Pobezinskaya Y,  Bishop J, Parke S,  Medzhitov R, Chervonsky AV, Golovkina TV.  2003.  Subversion of the innate immune system by a retrovirus.  Nature Immunol 4(6):573-578.

Purdy A, Case L, Duvall M, Overstrom-Coleman M, Monnier N, Chervonsky A, Golovkina T.  2003.  Unique resistance of I/LnJ mice to a retrovirus is due to sustained IFN-gamma dependent production of virus-neutralizing antibodies.  J Exp Med 197:233-243.

Pobezinskaya Y, Chervonsky AV, Golovkina TV.  2004.  Initial stages of mammary tumor virus infection are superantigen independent.  J Immunol 172:5582-5587.

Sarkar N, Golovkina TV, Uz-Zaman T.  2004.  RIII/Sa mice with a high incidence of mammary tumors express two exogenous strains and one potential endogenous strain of mouse mammary tumor virus.  J Virol 78(2):1055-1062.

Case LK, Purdy A, Golovkina TV.  2005. Molecular and cellular basis of the retrovirus-resistance in I/LnJ mice.
 J Immunol, 175:7543-7549.

MacDearmid CC, Case LK, Starling CE, Golovkina TV.  Gradual elimination of retroviruses in YBR/Ei mice.  2006, J Virology, 80(5):2206-2215.

Swanson I, Jude B, Zhang AR, Smith ZE, Pucker A, Golovkina TV.  Sequences within the gag gene of mouse mammary tumor virus needed for mammary gland cell transformation. 2006, J Virol 80(7):3215-24.  

Case LK, Petell L, Yurkovetskiy L, Purdy A, Savage KJ and Golovkina TV.  Replication of beta- and gammaretroviruses is restricted in I/LnJ mice via the same genetic mechanism.  2008, J Virol, 82(3):1438-1447.

Kane M, Case LK and Golovkina TV. Vital Role for CD8+ Cells in Controlling Retroviral Infections. 2011, J Virol, 85(7): 3415-3423.

Kane M, Case LK, Wang C, Yurkovetskiy L, Dikiy S, Golovkina TV.  Innate immune sensing of retroviral infection via Toll-like receptor 7 occurs upon viral entry.  2011, Immunity, 35: 135-145.   

Kane M, Case LK, Kopaskie K, Kozlova A, MacDearmid C, Chervonsky AV, Golovkina TV. Successful retroviral transmission depends on commensal microbiota, 2011, Science, 334:245-249.