Tatyana V. Golovkina, Ph.D.

APPOINTMENTS

  • Professor, Department of Microbiology, Committee on Immunology, Committee on Microbiology

CONTACT INFORMATION

The University of Chicago 
CLSC 711A
920 East 58th Street 
Chicago, Illinois 60637

tgolovki@bsd.uchicago.edu

Phone:  (773) 834-7988

RESEARCH SUMMARY

Tatyana received her M.S. in Biochemistry from Moscow State University, Moscow, USSR.  She pursued graduate studies at the USSR Academy of Medical Sciences Cancer Research Center, Moscow, USSR in the laboratory of Andrei Gudkov.  Her doctoral thesis describes studies on evolution of endogenous retroviruses in mammalian genome. She then joined Susan Ross’ laboratory at the Department of Biochemistry, University of Illinois at Chicago and later moved with the lab to University of Pennsylvania, Department of Microbiology. She joined The Jackson Laboratory in Bar Harbor, ME in 1997 where she studied genetics of resistance to viral infection and in 2005, she re-located her laboratory to the Department of Microbiology at the University of Chicago.

Tatyana’s laboratory uses different retroviruses to study distinct aspects of retrovirus-host interactions, including the anti-virus immune response and the genetics of resistance to retroviral infection and to virally induced tumors.  Recently her laboratory became interested in understanding the mechanisms by which commensal bacteria colonized in the gut influence the outcome of viral infections.  By using germ-free mice, they found that retroviruses that spread through the gastrointestinal route exploit commensal bacteria to induce tolerance to themselves.  Unresponsiveness of the infected host enables the viruses to persist indefinitely.  Elucidation of the mechanism of retroviral pathogenesis is of fundamental importance, as it will ultimately lead to increased knowledge about the anti-virus immune response in general and variations in susceptibility to viral infections in humans.

SELECTED PAPERS

Wilks, J. and T. Golovkina (2015). "Immunology. Interfering with interferons." Science 347(6219): 233-234.

Pickard, J. M., C. F. Maurice, M. A. Kinnebrew, M. C. Abt, D. Schenten, T. V. Golovkina, S. R. Bogatyrev, R. F. Ismagilov, E. G. Pamer, P. J. Turnbaugh and A. V. Chervonsky (2014). "Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness." Nature 514(7524): 638-641.

Wilks, J., H. Beilinson, B. Theriault, A. Chervonsky and T. Golovkina (2014). "Antibody-mediated immune control of a retrovirus does not require the microbiota." J Virol 88(11): 6524-6527.

Wilks, J., H. Beilinson and T. V. Golovkina (2013). "Dual role of commensal bacteria in viral infections." Immunol Rev 255(1): 222-229.

Kane, M. and T. Golovkina (2012). "Realities of virus sensing." Microbes Infect 14(12): 1017-1025.