Stephen Meredith, MD, PhD

appointments

  • Professor, Department of Pathology
  • Program Director, MPMM
  • Professor, Department of Biochemistry and Molecular Biology
  • Professor, Department of Neurology
  • Associate Faculty, The College of the University of Chicago Divinity School
  • Committee on Molecular Medicine/MPMM

education

Ph.D., The University of Chicago, 1982
M.D., Washington University in St. Lous, 1974

contact information

The University of Chicago
AMB N314
5841 South Maryland Avenue
Chicago, Illinois 60637

scmeredi@uchicago.edu

Phone: (773) 702-1267

Website (Department of Biochemistry and Molecular Biology)

research summary

Studying the Structure of Beta-amyloid Fibrils Using a Combination of Solution and Solid-state NMR, and Other Physical Methods, Notably Neutron and X-ray Scattering

selected publications

Papers in 2009:
Bockhorn JJ, Lazar KL, Gasser A, Luther LM, Qahwash IM, Chopra N, and Meredith SC, Novel Semi-synthetic Method for Generating Full Length β-Amyloid Peptides, submitted, Biopolymers.

Lanning JD and Meredith SC, Chaperone-like N-methyl Peptide Inhibitors of Polyglutamine Aggregation, submitted, Biochemistry.

Paravastu AK, Qahwash IM, Leapman RD, Meredith SC and Tycko R, Seeded growth of synthetic β-amyloid fibrils from Alzheimer’s brain-derived fibrils produces a novel fibril structure, Proc. Natl. Acad. Sci. USA. 106:7443-7448, 2009

Darnell GD, Derryberry JM, Kurutz JW, and Meredith SC, Flanking Polyprolines Induce Polyglutamine Aggregation as PPII Helices Through the Hydrophobic Effect, Biophys J. 97:2295-2305, 2009.

Chopra N, Gan W, Schreiber H, Kurutz JW, and Meredith SC. A Versatile Cyclic Template for Assembly of Peptides and Proteins, Bioconj. Chem. 20: 231-40, 2009.

Sciarretta KL, Orgel JPRO, Tycko R, and Meredith, SC. Evidence for Novel β-Sheet Structure in Iowa Mutation β-Amyloid Fibrils, Biochemistry 48:6072-6084, 2009.

Select Earlier Papers:
Lazar KL, Kurutz JW, Tycko R, Meredith SC, Encapsulation and NMR on an aggregating peptide before fibrillogenesis, J Am Chem Soc. 128:16460-16461, 2006.

Sciarretta KL, Gordon DJ, Meredith SC, Peptide-based inhibitors of amyloid assembly, Methods Enzymol. 413: 273-312, 2006.

Schietinger A, Philip M, Yoshida BA, Azadi P, Liu H, Meredith SC, Schreiber H, A mutant chaperone converts a wild-type protein into a tumor-specific antigen, Science 314: 304-308, 2006.

Gordon DJ, Balbach JJ, Tycko R and Meredith SC. (2004) Increasing the Amphiphilicity of an Amyloidogenic Peptide Changes the β-Sheet Structure in the Fibrils from Antiparallel to Parallel. Biophys. J., 86: 428-434.

Selected as New and Notable: 
Liming Hou and Michael G. Zagorski. (2004) Sorting Out the Driving Forces for Parallel and Antiparallel Alignment in the A-beta Peptide Fibril Structure , Biophys. J. 86: 1-2.

Lazar KL, Miller-Auer H, Getz GS, Orgel JP, Meredith SC, Helix-turn-helix peptides that form α-helical fibrils: turn sequences drive fibril structure, Biochemistry 44:12681-12689, 2005.