Stephen Kron, M.D., Ph.D.

APPOINTMENTS

  • Professor; Department of Molecular Genetics and Cell Biology; Ludwig Center for Metastasis Research; Committee on Cancer Biology; Committee on Molecular Medicine/MPMM; Committee on Genetics, Genomics, and Systems Biology

EDUCATION

M.D., Ph.D., Stanford University, 1990

M.S.E, University of Pennsylvania, 1983

B.A., University of Pennsylvania, 1982

CONTACT INFORMATION

The University of Chicago
GCIS W522
929 East 57th Street
Chicago, Illinois 60637

skron@uchicago.edu

Phone:  (773) 834-1815

Website (MGCB)

RESEARCH SUMMARY

Molecular, Chemical and Systems Biology of Cell Signaling, Cell Cycle and Checkpoint Response

The Kron laboratory is a diverse and collaborative group of cell biologists, geneticists, biochemists, chemists and computer scientists. Our current basic research and technology efforts include 1) defining roles for chromatin dynamics and cell cycle regulation in DNA damage checkpoint response and cellular senescence, 2) dissecting cross-talk between metabolism and DNA damage response, 3) developing novel molecular assays to interrogate cell signaling in cancer, and 4) implementing novel mass spectrometry approaches to enable quantitative proteomics. We also pursue translational projects directed at 1) discovering inhibitors of cellular response to DNA double strand breaks as an approach to radiosensitization, 2) examining DNA damage and repair in tissues and tumors, and 3) exploiting DNA damage responses to induce anti-tumor immune responses.

Research Papers in PubMed