Sean Crosson

APPOINTMENTS

  • Professor, Department of Biochemistry and Molecular Biology, Committees on Microbiology and Genetics, Genomics and Systems Biology

EDUCATION

Postdoc, Stanford University, 2003-2005
Ph.D., The University of Chicago, 2002
B.A., Earlham College, 1996

CONTACT INFORMATION

The University of Chicago
GCIS W138
929 East 57th Street
Chicago, Illinois 60637

scrosson@uchicago.edu

Phone:  (773) 834-1926

Lab:       (773) 702-0439

Lab: http://crescentus.bsd.uchicago.edu

Chicago Center for Functional Annotation: www.ucfunction.org

RESEARCH SUMMARY

Regulatory mechanisms controlling bacterial cell physiology and infection biology

My group investigates the molecular basis of environmental 
adaptation in bacteria that inhabit niches 
ranging from freshwater, to soil, to the 
interior of mammalian cells.  We utilize a
 cross-disciplinary set of experimental and computational tools to understand regulatory mechanisms that enable bacterial cells to adapt their growth to changing environments.

Our studies primarily center on the freshwater bacterium Caulobacter crescentus and the related human pathogen Brucella abortus, which is the causative agent of the global zoonotic disease known as brucellosis.  Research in the lab includes:

1) Functional, structural, and biophysical characterization of light/redox protein sensors

2) Genetic and structural studies of bacterial metabolic and cell cycle control systems

3) Structural, functional, and computational studies of the alphaproteobacterial general stress signaling system, including its role in chronic brucellosis

4) Development of new antimicrobial treatment strategies

SELECTED PAPERS

Research Papers in PubMed