Marjorie and Robert E. Straus Professor in Neurological Science, Department of Neurology, Committee on Immunology, Committee on Microbiology, Committee on Molecular Medicine/MPMM, Committee on Neurobiology
Director, Amyotrophic Lateral Sclerosis (ALS)/Motor Neuron Disease Clinic
M.D., SUNY Downstate Medical Center, 1968
A.B., Columbia College, New York, 1964
The University of Chicago
Ab 616, (MC 2030)
5841 South Maryland Avenue
Chicago, Illinois 60637
Phone: (773) 702-5659
Secretary: (773) 702-5659
Website (Med Center)
Picornaviral Genes and Gene Products Critical in Determining Their Biological Properties (Neurovirulence, Persistence, Demyelinating Activity); Pathogenesis of Unconventional Viral Infections of the Central Nervous System; Pathogenesis of Amyotrophic Lateral Sclerosis
My main interests are central nervous system (CNS) viral infections and neurodegenerative diseases. A basic goal of my studies is to use molecular techniques to better understand the pathogenesis of these diseases. We have the following main research directions:
1. Investigate disease induced by picornaviruses (poliovirus and Theiler’s virus) in order to identify molecular determinants for neurovirulence, virus persistence and demyelination, and the mechanisms involved. The identification of virus genes important in these phenotypes may not only clarify the pathogenesis of the virus diseases but also lead to an understanding of genes important in the normal CNS function and in human CNS disease states (such as amyotrophic lateral sclerosis and multiple sclerosis).
2. Delineate genes and gene products critical to the death and survival of neurons, especially related to neurodegenerative diseases such as amyotrophic lateral sclerosis.