Michael Spiotto, M.D., Ph.D.


  • Assistant Professor, Department of Radiation & Oncology, Cancer Research Center, Committee on Cancer Biology


M.D., University of Chicago, 2005
Ph.D. University of Chicago, 2003


The University of Chicago
KCBD 6220
900 East 57th Street 
Chicago, Illinois 60637


Phone:  (773) 702-3086


For the treatment of solid tumors, current therapies involving a combination of radiation, surgery and/or chemotherapy often achieve local control exceeding 60-70% even in very advanced cases. However, distant relapses often portend a dismal prognosis. Using models of head and neck cancer and breast cancer, we  are developing new ways to study and to treat metastatic cancer. The ongoing project in our group

1. Development of in vivo screens for  genes involved in the metastasis of primary tumors of the oral cavity. Squamous cell carcinomas of the oral cavity have a high propensity for regional and distant spread resulting in a 5 year overall survival of  50% in locally advanced cases. Here, we are developing transgenic models to identify genes involved in lymph node and solid organ metastasis of primary oral cavity tumors.

2. Development of targeted inhibitors for human papilloma virus (HPV).
HPV positive cancers occur in the head and neck as well as other sites including cervix and anus. Here, we are developing systems for high throughput screens of the oncogenic HPV proteins E6 and E7.

View Research Papers on PubMed