Marsha R. Rosner, Ph.D.

APPOINTMENTS

  • Charles B. Huggins Professor, Ben May Department for Cancer Research, Department of Neurobiology - Pharmacology and Physiology, UCCCC, Committee on Cancer Biology, Committee on Developmental Biology

EDUCATION

Ph.D., Massachusetts Institute of Technology, 1978

CONTACT INFORMATION

The University of Chicago
GCIS W421C
929 East 57th Street
Chicago, Illinois 60637

E-Mail: mrosner@uchicago.edu

Phone:  (773) 702-0380

Website (Ben May)

RESEARCH SUMMARY

Growth Factor Receptor Signaling Leading to Cell Growth, Cell Differentiation or Cell Death

Growth factor-mediated signal transduction is a process that is of fundamental importance in understanding cellular growth and differentiation. In recent years, a number of laboratories including my own have devoted considerable effort toward elucidating the mechanisms by which initiation of signal transduction by growth factors is regulated. We have focused many of our recent studies on the mechanisms by which the epidermal growth factor (EGF) receptor is regulated, with particular emphasis on heterologous regulation of exogenous growth modulators such as novel tumor promoters, retinoids and transforming growth factor-beta. Depending on the agent, this type of regulation can be stimulatory at the level of genetic expression of the receptor, or inhibitory at the level of biochemical regulation of receptor activity. During the past few years we have been isolating and characterizing the enzymes involved in the EGF signal transduction cascade, which are also important in the regulation of the EGF receptor itself. We have also investigated a number of growth modulators that alter transcription of the EGF receptor, and we have identified the domains within the EGF receptor promoter that are important for regulation by these agents. In addition, we have cloned, expressed and characterized a growth factor protease for transforming growth factor-alpha and insulin-related factors from both human and Drosophila sources that is highly conserved evolutionarily. This enzyme is a member of a newly emerging family of metalloproteinases that act as processing enzymes in species ranging from yeast to man. We plan to use this system to address the important problem of regulation of signal transduction by proteolytic degradation. Finally, we have focused our most recent efforts on elucidation of the signal transduction cascades leading to the differentiation of neuronal cells. Using conditionally immortalized CNS cell lines that we have generated, we have demonstrated that EGF stimulates growth but not differentiation of the cells, whereas fibroblast-derived growth factor can induce neuronal differentiation at the nonpermissive temperature. We are currently characterizing the kinase cascade leading to neuronal differentiation by growth factors and cloning novel genes that are regulated by this process.

Research Papers on PubMed