Marcus Clark, M.D.


  • Professor, Department of Medicine, Section of Rheumatology, Cancer Research Center, Committee on Immunology, Committee on Molecular Medicine/MPMM
  • Chief, Section of Rheumatology
  • Co-Director, Knapp Center for Lupus and Immunology Research


M.D., University of California, Los Angeles, 1984
B.A., University of California, Riverside, 1981


The University of Chicago
JFK R310
924 East 57th Street
Chicago, IL  60637

Phone:  (773) 702-0202

Website (Medical Center)

Website (Knapp Center)


B Cell Development and Activation

Our laboratory has a long-standing interest in B cell antigen receptor (BCR) signaling and how BCR dependent processes regulate specific cell fate decisions.  In the bone marrow, we have been working to understand how signals initiated through the pre-BCR, in conjunction with those delivered through the IL-7 receptor, coordinate cell cycle progression with immunoglobulin light chain recombination. In the periphery, we have focused on the molecular mechanisms of receptor endocytosis and endocytic trafficking and how these mechanisms influence BCR trafficking and cell fate.  For both our work on B lymphopoiesis and BCR endocytic trafficking, we have derived novel in vivo models, and have performed directed in vitro studies, to obtain definitive insights into these processes.  We have also been applying our knowledge of B cell biology to understand how in situ adaptive immune responses drive tubulointerstitial inflammation in human lupus nephritis. We have been productive in all of these project areas.  In addition, I have used my expertise in B cell biology and human autoimmunity to establish a NIH-funded Autoimmunity Center of Excellence. This center is providing a collaborative platform for human-focused autoimmune studies in Rheumatology, Neurology, Gastroenterology and Nephrology.  In addition to research, my other focus is on mentoring and education. I have extensive experience in research mentoring including serving as the primary advisor for nine graduate students and over 30 clinical and postdoctoral fellows. For the last five years, I have been the Director of the University of Chicago Medical Scientist Training Program. This position allows me to apply my expertise in fundamental research, translational biology and clinical care to the training of the next generation of leaders in academic medicine. 

Research Papers in PubMed