Lucia Schuger, M.D.

APPOINTMENTS

  • Professor, Department of Pathology, Committee on Molecular Medicine/MPMM

EDUCATION

M.D., Univ.of Buenos Aires, Argentina

CONTACT INFORMATION

The University of Chicago

5841 South Maryland Avenue
AMB J541 / MC 1089
Chicago, Illinois 60637

lschugar@uchicago.edu

Phone:  (773) 702-4784

Website (Dept. Of Pathology)

RESEARCH SUMMARY

Pulmonary Pathology

I study the genetic program of smooth muscle (SM) myogenesis, which is central to the pathogenesis of cardiovascular disease, asthma, and all pathological conditions involving myofibroblast-mediated fibrosis. The focus is on the identification of genes involved in SM myogenesis and the study of their functional role in health and disease. Towards this end, we put considerable effort in utilizing the most powerful research tools available; whether in our lab, in core facilities, or by teaming with other investigators. Our projects are currently focused on P311 and the TIPs (Tension Induced/inhibited Proteins) family, the products of two genes we previously identified as being differentially expressed during myogenesis. Among the many projects ongoing in our laboratory right now are: 1) the characterization of tip KO mice we recently generated; 2) the elucidation of P311 function at the molecular level. Specifically, after discovering that P311 regulates blood pressure and it does so by controlling the systemic levels of TGF-bs, we are investigating the mechanisms underlying this important P311 function; 3) the determination of P311 involvement in lung fibrosis and skin hypertrophic scarring; two of the many pathological processes in which TGF-bs play a key role; 4) the study of lymphangioleiomyomatosis (LAM) genetics. LAM is a rare but fatal disease affecting young women. This disease is characterized by the infiltration and cystic destruction of the lung by proliferating abnormal SM cells. The LAM project encompasses several subprojects; one of them is wide genomic analysis of LAM cells, collected by laser microdissection from lungs of LAM patients during lung transplant. 

View Research Papers on PubMed