Haochu Huang, Ph.D.

APPOINTMENTS

  • Associate Professor, Department of Medicine, Committee on Immunology

EDUCATION

Ph.D., Johns Hopkins University,  2000

CONTACT INFORMATION

The University of Chicago
924 East 57th Street
JFK R412,  (MC 6079)
Chicago, IL 60637

hhuang@bsd.uchicago.edu

Phone:  (773) 834-4482

RESEARCH SUMMARY

Tolerance and Autoimmunity

Our laboratory is interested in understanding how autoreactive T and B cells are regulated in normal immune system and what goes wrong in autoimmunity. Tolerance of the immune system to self-antigens is established and maintained by both central and peripheral tolerance mechanisms and is essential for avoiding autoimmunity. Central tolerance is mediated by clonal deletion of autoreactive thymocytes. This negative selection requires that self-antigens are efficiently presented by antigen-presenting cells (APCs) to developing thymocytes. Particularly we are interested in the development and role of thymic B cells.  Although the presence of B cells in the thymus has been recognized for several decades, their function is not well understood.  Our working model is that thymic B cells are efficient APCs in mediating negative selection of T cells for antigens that are recognized by their BCRs and as such contribute to shaping the T cell repertoire. The second direction of our research is on peripheral tolerance. Major questions tackled are how autoreactive T cells get activated and how gut microbiota affects this process. We utilize the K/BxN mouse model of rheumatoid arthritis for these studies.

Research Papers in PubMed