Dorothy Hanck, Ph.D.

APPOINTMENTS

  • Professor, Department of Medicine - Section of Cardiology, Committee on Molecular Medicine/MPMM, Committee on Neruobiology, Committee on Cell Physiology, Committee on Computational Neuroscience

EDUCATION

Ph.D., Temple University, 1981

CONTACT INFORMATION

The University of Chicago
AMb M602/MC 6094
5841 South Maryland Ave.
Chicago, Illinois 60637

dhanck@uchicago.edu

Phone: (773) 702-1758

Website (Committee on Neurobiology)
Website (Department of Medicine)

RESEARCH SUMMARY

My laboratory provides an integrated environment of electrophysiological, molecular biological, and modelling facilities for the study of basic biophysics and physiology of ion channels in health and disease. My research focuses on cardiac ion channel biophysics, physiology, and pharmacology with the goal of identifying heart specific characteristics and their structural bases that can be used to direct rationale drug design. On-going projects target specifically the cardiac Na channel including its intrinsic kinetics, metabolic regulation by phosphorylation, and interaction with clinically used antiarthythmic drugs. In addition, complementary studies on other isoforms of this channel, as found in the nervous and endocrine system as well as studies of potassium and calcium channels are also supported. The use molecular biological techniques to investigate the structural basis of channel behavior is supported and encouraged. The laboratory provides a full range of electrophysiological techniques, including (a) whole cell voltage clamp, (b) single channel recording, and (c) gating current recording. These techniques can be combined to study native channels in acutely isolated single myocytes and in cultured cells. The structural bases of functional characteristics identified in native cells can be pursued in several expression systems, including Xenopus oocytes, transiently transfected mammalian cells, and stable cell lines for a variety of cloned channels. In addition to experimental work, the laboratory offers a wide variety of computer based graphics and modelling tools for quantitative analyses and opportunities to test theory with experimental data.

Research Papers in PubMed